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Breast Cancer

Women treated with trastuzumab have increased risk of metastases to the brain

Published in Women's Health Weekly, June 26th, 2003

Patients with metastatic breast cancer who receive the anticancer drug trastuzumab have a higher frequency of central nervous system (CNS) cancer than expected.

Findings reported in the June 15, 2003 issue of Cancer indicate that more than 33% of women with metastatic breast cancer who overexpress the HER2 receptor and are treated with trastuzumab, develop symptomatic CNS metastases, often times in spite of decreased or stable metastatic disease elsewhere in the body.

The authors suggested that because of the devastating impact of neurological impairment and the high incidence of brain metastases while on trastuzumab, "it may be worthwhile to...

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