Osteoporosis
Adenovirus-mediated VEGF-A gene delivery boosts bone formation
Published in Women's Health Weekly, June 26th, 2003
"Osteoporosis is a major problem in elderly population. We tested the hypothesis whether vascular endothelial growth factor (VEGF-A) gene transfer is an appropriate way to enhance bone formation and recruitment of osteoblasts in vivo," researchers in Finland reported.
"Adenovirus vectors containing VEGF-A or lacZ cDNAs (1.4x1010 pfu) were injected locally into right distal femurs of New Zealand White rabbits. Saline was injected into all contralateral distal femurs. One and three weeks after the gene transfers femurs were collected for analyses," said M.O. Hiltunen and...
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