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Ovarian Cancer

Phenoxodiol induces apoptosis in chemoresistant ovarian cancer cells

Published in Women's Health Weekly, July 3rd, 2003

Phenoxodiol induces apoptosis in chemoresistant ovarian cancer cells. According to published research from the United States, "Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation.

"In this study we characterize the cytotoxic effect of phenoxodiol, a synthetic anticancer drug analog of genestein, and demonstrate the mechanism of action by which phenoxodiol affects the components of the Fas apoptotic pathway on ovarian cancer cells," wrote M. Kamsteeg and colleagues, Yale University School of Medicine.

"Primary ovarian cancer cells, isolated from ascitic fluids of ovarian cancer patients,...

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