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Contraception

Gamma-inulin/liposomes/vitamin E adjuvant used in contraceptive vaccines

Published in Women's Health Weekly, July 10th, 2003

A combination adjuvant composed of gamma-inulin, liposomes, and vitamin E promoted the formation of antibodies against sperm.

"The adjuvanticity of two gamma inulin/liposomes/vitamin E combinations was evaluated in the mouse, in contraceptive vaccines with sperm protein extracts or a synthetic HE2 peptide (human epididymis gene product; residues 15-28) as antigen. The HE2 peptide was not conjugated to a protein carrier, to ensure that the antibodies elicited were specific against the HE2 peptide," scientists in Spain report.

"The adjuvant combinations were designed to increase adjuvanticity, as their components have complementary mechanisms, and...

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