Breast Cancer
JNK/SAPK pathway activation may be a therapeutic intervention in breast cancer
Published in Women's Health Weekly, August 14th, 2003
"Pharmacologic induction of cancer cell differentiation has potential in the treatment of breast cancer," scientists in the United States report.
"Doxorubicin, a widely used anthracycline antibiotic, was previously reported to induce differentiation of MCF-7 breast cancer cells," wrote J. Kim and colleagues, Children's Hospital, John F. Enders Research Laboratories.
"We demonstrate in this study that inhibition of MCF-7 breast cancer cell growth by low dose doxorubicin (0.01 microg/ml) was accompanied by an increase in cytokeratin 8/18 and milk fat...
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