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Pregnancy

Maternal serum IL-10 is elevated but constant during normal pregnancy

Published in Women's Health Weekly, August 21st, 2003

Serum IL-10 levels in mothers are elevated but constant during normal pregnancy and immediately post-partum.

According to a study from North Ireland, "Pregnancy is proposed to be a Th2 phenomenon, where Th2 cytokines inhibit Th1 responses to improve fetal survival. The importance of interleukin-10 (IL-10), an immunomodulatory cytokine produced by Th2 cells, in the maintenance of normal pregnancy is becoming increasingly apparent. In a longitudinal case control study, the physiological effect of pregnancy on plasma IL-10 was investigated.

"The plasma concentration of IL-10 was determined using an ELISA technique in 99 pregnant women sampled at 12, 20...

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