Vector Development
Better gene expression can be attained with modified adeno-associated virus
Published in Women's Health Weekly, September 4th, 2003
"Correction of diseases may be achieved by delivery of genes to stem cells and developing organ systems. Our previous studies demonstrated life-long expression after in utero injection of adeno-associated virus (AAV) serotype 2 in mice. In the present studies, we compared levels of expression using the elongation factor 1alpha (EF1alpha) or the CMV promoter in AAV2 and AAV5 linked to luciferase via intraperitoneal injection in day 15 fetuses in utero," scientists in the United States reported.
"An additional AAV construct also contained the woodchuck hepatitis virus...
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