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Breast Cancer

Tumor tissues overexpress genes for the extracellular matrix protein BNF-1

Published in Women's Health Weekly, September 18th, 2003

Tumor tissues overexpress genes for the extracellular matrix protein BNF-1.

"In an effort to identify novel genes relevant to tumor angiogenesis, we compared the genes expressed in a matched pair composed of vascularized breast tumor and its adjacent normal tissue obtained from the same cancer patient. Using differential display, we identified a cDNA fragment that was reproducibly upregulated in vascularized breast tumor. Up-regulation of this gene fragment in vascularized breast tumor was further verified by semi-quantitative PCR on the same RNA pair using gene-specific primers," according to recent research from the United States.

"The cDNA...

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