Fetal Development
Sex chromosome dosages play a role in murine placenta size
Published in Women's Health Weekly, September 18th, 2003
"Mice of the XO genotype with a paternally derived X chromosome ((XO)-O-p) have placental hyperplasia in late pregnancy, although in early pregnancy the ectoplacental cone, a placental precursor, is smaller in (XO)-O-p mice than in their XX sibs. This early size deficiency of the ectoplacental cone is apparently a consequence of X-p imprinting, because (XO)-O-m embryos (with a maternally derived X chromosome) are unaffected. In the present study we sought to establish whether (XO)-O-p placental hyperplasia in late pregnancy is also a consequence of X-p imprinting," investigators in England said.
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