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Toxicology

Topical corticosteroid use during pregnancy may associate with cleft lip

Published in Women's Health Weekly, September 25th, 2003

Topical corticosteroid use during pregnancy may associate with cleft lip.

"A case-control survey of 48 children with nonsyndromic cleft lip or palate showed a significant increase in prevalence of maternal use of topical corticosteroid preparations in the first trimester of pregnancy, compared to 58 controls born in the same hospital; the odds ratio was 13.154, 95% confidence interval 1.67-586, p=0.0049 on Fisher's exact two-tail test," wrote researches in Australia.

"The results were statistically significant although the wide confidence interval reflected the small sample size. Although older epidemiological studies have not detected any...

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