Environmental Health
The perinatal period marks the greatest odds for changes in dosimetry values
Published in Women's Health Weekly, September 25th, 2003
According to recent research from the United States, "in recent years efforts have increased to develop a framework for assessing differences, both pharmacokinetic and pharmacodynamic, between children and adults for purposes of assessing risk of adverse effects following chemical exposure. The specific goal of this study was to demonstrate an approach for using PBPK modeling to compare maternal and fetal/neonatal blood and tissue dose metrics during pregnancy and lactation."
"Six chemical classes were targeted to provide a variety of physicochemical properties (volatility,...
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