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Breast Cancer

Low levels of PPARgamma and PGC-I are associated with poor clinical outcomes

Published in Women's Health Weekly, October 16th, 2003

Low levels of PPARgamma and PGC-I are associated with poor clinical outcomes.

"Peroxisome-proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as receptor for peroxisome-proliferators, steroids, retinoic acids, and polyunsaturated fatty acids," investigators in Wales report.

"Our study examined the transcript levels of peroxisome-proliferator activated receptorgamma (PPARgamma) and its co-activator (PGC-I) in a cohort of patients with breast cancer. An invasive breast cancer cell, MDA MB 231 exhibited lower level of expression of PPAR-gamma compared to noninvasive MCF-7," wrote W.G. Jiang and colleagues,...

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