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Microbiology

Response to environmental changes in pH is a hallmark of Candida albicans

Published in Women's Health Weekly, November 20th, 2003

Response to environmental changes in pH is a hallmark of Candida albicans infection.

"For microorganisms that grow over a wide range of extracellular pH, systems must have evolved to sense and respond appropriately. The human opportunistic pathogen Candida albicans colonizes and infects anatomical sites of diverse pH, including the oral and gastrointestinal tracts and the vaginal cavity," according to researchers in the United States.

"The ability to sense and respond to neutral-alkaline environments is governed by signal transduction pathways, one of which culminates in the activation of the transcription factor, Rim101p," suggested D....

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