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Gynecology

Systemic ketorolac relieves the pain of uterine cervical distension

Published in Women's Health Weekly, November 27th, 2003

Systemic ketorolac relieves the pain of uterine cervical distension.

According to recent research published in the journal Pain, "cyclooxygenase inhibitors demonstrate effective antinociception in many clinical and experimental pain models. Acute uterine cervical distension (UCD) forms the basis for obstetric and some gynecologic pain, and acute UCD in rats results in nocifensor reflexes which are inhibited by morphine in animals lacking, but not in animals with circulating estrogen. We studied the antinociceptive effect of intravenous and intrathecal injection of the cyclooxygenase inhibitor, ketorolac in acute UCD rats and its dependency on estrogen."

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