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Breast Cancer

Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 breast cancer

Published in Women's Health Weekly, December 4th, 2003

Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 breast cancer.

"Reactive oxygen species (ROS) cause cell death and are associated with a variety of maladies, from trauma and infection to organ degeneration and cancer. Cells mount a complex response to oxidative damage that includes signaling from transmembrane receptors and intracellular kinases," scientists in the United States report.

"We have analyzed the response to oxidative damage in human breast cancer cells expressing the Hpr6.6 (human membrane progesterone receptor) protein. Although Hpr6.6 is related to a putative progesterone-binding protein, Hpr6.6 is widely expressed in...

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