Cervical Cancer
KCl cotransport is an important modulator of cervical cancer growth and invasion
Published in Women's Health Weekly, December 11th, 2003
According to a study from Taiwan, "Cervical cancer is a major world health problem for women, but the pathophysiology of this disease has received scant attention.
"Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and cellular osmotic homeostasis. Functional assays of KCl cotransport activation by osmotic swelling, staurosporine, and N-ethylmaleimide indicate that removal of the N-terminal 117 amino acids from KCC1 produces a...
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