Obstetrics
Growth factor involved in trophoblast differentiation is regulated by oxygen
Published in Women's Health Weekly, December 25th, 2003
"The transforming growth factor-beta3 (TGF-beta3) is involved in oxygen-dependent differentiation processes during placental development and pregnancy disorders. However, the importance of oxgen partial pressure for the regulation of TGF-beta3 expression is presently unclear. We and others presented preliminary evidence that the hypoxia-inducible factor-1 (HIF-1) confers TGF-beta3 transcription but it was unknown whether this occurred directly or indirectly," scientists writing in the journal Placenta report.
"To analyze how HIF-1 regulates TGF-beta3 gene...
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