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Enzymology

A human enzyme and maternal age influence how smoking affects birthweight

Published in Women's Health Weekly, December 25th, 2003

A human enzyme and maternal age influence how smoking affects birthweight.

According to scientists writing in the American Journal of Human Biology, "we investigated the possible effects of placental alkaline phosphatase (PLAP) genotype on the deleterious action of maternal smoke on intrauterine survival and birthweight. PLAP is a highly polymorphic enzyme with several alleles associated with different enzymatic activities. PLAP is produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy."

"Two hundred and fourteen Caucasian consecutive newborn infants delivered...

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