Breast Cancer

Declining estrogen receptor-beta expression defines progression of breast cancer

Published in Women's Health Weekly, January 22nd, 2004

The tissue concentration, relative occurrence, and/or interaction of estrogen receptor (ER)- alpha and ER-beta may play an important role in modulating mammary tumorigenesis.

"It has been shown that the risk of breast cancer developing in certain morphologically identifiable benign breast lesions correlates with expression of ... ER-alpha," scientists in England report.

"Although ER-alpha and ER-beta genes share a large degree of homology, it is generally thought that their distribution and functions are substantially different in many tissues. Recent development of reliable antibodies to ER-beta has provided this first opportunity to test the...

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Source: Women's Health Weekly (2004-01-22)

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