Breast Cancer

Novobiocin reverses breast cancer resistance protein BCRP/ABCG2

Published in Women's Health Weekly, January 22nd, 2004

Novobiocin can overcome breast cancer resistance protein (BCRP/ABCG2) mediated drug resistance at acceptable concentrations.

"Breast cancer resistance protein of an ATP-binding cassette half-transporter confers resistance against mitoxantrone and camptothecin derivatives of topotecan and irinotecan," scientists writing in the International Journal of Cancer report.

"Novobiocin, a coumermycin antibiotic, is known to enhance anticancer drug sensitivity of cancer cells in vitro and in vivo, the mechanism of which remains undetermined. Here we focused on drug efflux pump and examined whether novobiocin reversed drug resistance in...

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Source: Women's Health Weekly (2004-01-22)

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