Breast Cancer

Tamoxifen has no effect on p27 protein expression in endometrium

Published in Women's Health Weekly, January 22nd, 2004

Tamoxifen therapy had no effect on the expression of p27 protein in the endometrium of women with primary breast cancer.

"The cyclin-dependent kinase inhibitor, p27, has been shown to mediate cell growth arrest thereby significantly reducing the percentage of proliferating cells. It seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis. Our aim was to demonstrate the effects of tamoxifen therapy on the expression of p27 protein in the endometrium of postmenopausal breast cancer patients," scientists in Brazil report.

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Source: Women's Health Weekly (2004-01-22)

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