Breast Cancer
Dysregulation of RbAp46 expression may contribute to breast cancer tumorigenesis
Published in Women's Health Weekly, January 29th, 2004
"The retinoblastoma (Rb) suppressor associated protein 46 (RbAp46) is a subunit of chromatin modifying and remodeling complexes. Previously, we found that RbAp46 functions as a potent growth inhibitor. It is also a downstream effector of the Wilms' tumor suppressor, WT1," scientists writing in the journal Anticancer Research report.
"The findings that expression levels of WT1 were down-regulated in breast cancer cell lines and in subsets of primary breast tumors led us to investigate the possible role of RbAp46 in breast cancer...
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