Tail-temperatures of estrogen-deficient rats simulate menopausal hot flushes

According to a study from Netherlands, "the purpose of the present study was to further evaluate the tail-temperature test as a tool to test potential steroidal and non-steroidal compounds for the treatment of hot flushes. Ovariectomized rats were implanted with a temperature sensitive probe. After a recovery period of 5 weeks, the effect of estradiol (given via a silastic tube) and the 5-HT2 receptor antagonist mirtazapine (10 mg/kg i.p.) on the tail-temperature in the active phase of the animals was measured."

"Estradiol completely restored the disturbed tail temperature...

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