Toxicology
Preimplantation exposure to estradiol or methoxychlor alters sexual development
Published in Women's Health Weekly, April 8th, 2004
"Long-term effects of in vivo exposures to proestrogen methoxychlor (MXC) or estradiol-17beta (E) were studied during early pregnancy (preimplantation) in ICR mice. Pregnant dams received either subcutaneous injections of 1 microgram of E on day 2 of pregnancy only (vaginal plug = day 1), or 5.0 mg of MXC on days 2-4 of pregnancy in sesame oil," researchers in the United States report.
"Pregnant control mice were treated with the vehicle only. Litter size, postnatal survival, sex ratio at birth, and anogenital distance (AGD) in offspring of both sexes were examined, as...
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