Obstetrics
Factor V gene polymorphisms leave Finnish women vulnerable to preeclampsia
Published in Women's Health Weekly, April 8th, 2004
According to research from Finland, "this study determines whether genetic variability in the gene-encoding factor V contributes to differences in preeclampsia susceptibility. Allele and genotype frequencies of three single-nucleotide polymorphisms (SNPs) in the factor V gene leading to nonsynonymous changes (M385T in exon 8, and R485K and R506Q (Leiden mutation) in exon 10) were studied in 133 Caucasian women with preeclampsia and 112 healthy controls. Single-point analysis was expanded to haplotype analysis, and haplotype frequencies were estimated using an expectation-maximization...
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