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Cancer

Positive pre-clinical results announced for OXi4503 in cancer models

Published in Women's Health Weekly, April 29th, 2004

OXiGENE, Inc. (OXGN) announced the presentation of new data showing pre-clinical efficacy of the company's lead second-generation vascular targeting agent (VTA), OXi4503, in several human cancer models.

Professor Klaus Edvardsen, MD, PhD, evaluated the synergistic effects of OXi4503 with standard-of-care chemotherapy drugs Carboplatin and Paclitaxel in the MDA-MB-231 human breast adenocarcinoma and the ES-2 ovarian carcinoma models grown in mice.

"At doses ranging from 10 to 50 mg/kg, OXi4503 significantly enhanced the anti-tumor effects of the chemotherapeutic agents," said Dai Chaplin, PhD, OXiGENE's chief scientific officer and head of research...

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