Radiation Therapy
Antitumor HDAC inhibitors promote wound healing following radiation
Published in Women's Health Weekly, May 13th, 2004
"Radiotherapy is an effective treatment for head and neck, skin, anogenital, and breast cancers. However, radiation-induced skin morbidity limits the therapeutic benefits. A low-toxicity approach to selectively reduce skin morbidity without compromising tumor killing by radiotherapy is needed," wrote scientists in the journal Molecular Cancer Therapeutics.
Data show that "antitumor agents known as histone deacetylase (HDAC) inhibitors (phenylbutyrate, trichostatin A, and valproic acid) could suppress cutaneous radiation syndrome. The effects of HDAC inhibitors in promoting...
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