Tobacco Use
In utero nicotine exposure has a negative effect on fetal brain tissues
Published in Women's Health Weekly, May 13th, 2004
According to a study from Turkey, "histopathological changes in the brains of embryos from female rats treated with nicotine during pregnancy and possible involvement of nitric oxide (NO) and catecholamines in the nicotine-induced abnormalities of developing brain were investigated. Sexually mature female Wistar rats were given 1, 2, and 3 mg/kg nicotine hydrogen tartrate (NHT) subcutaneously for 20 days after mating. Levels of cotinine, a nicotine metabolite, in the maternal plasma increased dose-dependently.
"Fetus and fetal brain weights were significantly lower in all...
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