Women's Health Weekly
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Breast Cancer
Estrogen receptor-alpha mutation K303R not found in Japanese breast carcinomas
May 13th, 2004
Estrogen receptor-alpha mutation K303R was not found in Japanese breast carcinomas. A "common somatic mutation, A-to-G transition at nucleotide 908, in the estrogen receptor-alpha (ERalpha) gene has" recently been reported. This mutation causes an amino acid change in the ER hinge domain (lysine 303 to arginine, K303R) and confers an increased sensitivity to estrogen and an increased cellular proliferative potential. This mutation has been observed more frequently in breast cancers than in premalignant lesions," wrote scientists in Japan. "According to previously published reports, the mutation was found in 62% of invasive breast cancers, 85% of the...
Source: Women's Health Weekly (2004-05-13)
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