Women's Health Weekly
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Breast Cancer
Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo
May 13th, 2004
Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo. "The effect of monoterpene perillyl alcohol (POH) on cell growth, cell cycle progression, and expression of cell cycle-regulatory proteins in estrogen receptor (ER)-positive (KPL-1 and MCF-7) and ER-negative (MKL-F and MDA-MB-231) human breast cancer cell lines was examined. POH inhibited cell proliferation in a dose-dependent manner in all cell lines tested. POH at a dose of 500 mcM had a cytostatic effect, in which growth inhibition was due to accumulation of cells in G1-phase," wrote investigators in Japan. "Cell cycle progression was preceded by a decrease in G1 cyclins (...
Source: Women's Health Weekly (2004-05-13)
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