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Endocrinology

Sex steroids influence the effects DHEA has on cognition in menopausal women

Published in Women's Health Weekly, May 13th, 2004

Sex steroids influence the effects DHEA has on cognition in menopausal women.

"Prior studies of the effects of dehydroepiandrosterone (DHEA) on cognition have produced complex and inconsistent results. We hypothesize that these results may arise, in part, because of DHEA's metabolism into estrogens and androgens that produce opposing effects on cognition. Our study administered 50 mg of oral DHEA daily for 4 weeks in a placebo-controlled crossover design to six postmenopausal women," investigators in the United States report.

"We measured blood levels of androgens (total testosterone, free testosterone, DHEA, DHEAS), estrogens (estradiol, estrone),...

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