Women's Health Weekly

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Women's Health Weekly


We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Drug Development

2-Methoxy- and 2-ethyl-estrogen sulfamates curtail angiogenesis in vitro

"Sulfamoylation of 2-methoxyestrone (2-MeOEI) was shown previously to enhance its potency as an anti-proliferative agent against breast cancer cells. We have examined the ability of a series of 2-methoxyestradiol (2-MeOE2) and 2-ethylestradiol (2-EtE2) sulfamates to inhibit angiogenesis in vitro," researchers in England report.

"2-MeOE2 bis-sulfamate and 2-EtE2 sulfamate were potent inhibitors of human umbilical vein endothelial cell (HUVEC) proliferation with IC₅₀ values of 0.05 mcM and 0.01 mcM, respectively. A novel coculture system, in which endothelial cells...

• View Other Issues of Women's Health Weekly
  
• View Other NewsRx Publications