Women's Health Weekly
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Endocrionology
High glucocorticoid levels reduce bone formation
May 13th, 2004
High glucocorticoid levels reduce bone formation. According to recent research from the United States, "whether the negative impact of excess glucocorticoids on the skeleton is due to direct effects on bone cells, indirect effects on extraskeletal tissues, or both is unknown. To determine the contribution of direct effects of glucocorticoids on osteoblastic/ osteocytic cells in vivo, we blocked glucocorticoid action on these cells via transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2, an enzyme that inactivates glucocorticoids. Osteoblast/ osteocyte- specific expression was achieved by insertion of the 11beta-hydroxysteroid dehydrogenase type 2 cDNA...
Source: Women's Health Weekly (2004-05-13)
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