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Osteoporosis

Linkage analysis: Chromosomal loci regulate bone mass at varied skeletal sites

Published in Women's Health Weekly, May 27th, 2004

Results of a linkage study using the linear combination of several correlated bone phenotypes suggest chromosomal loci regulate bone mass at different skeletal sites.

D. Karasik and colleagues at the Harvard University School of Medicine's Division of Aging described their work in the journal Bone (Genome screen for a combined bone phenotype using principal component analysis: the Framingham study. Bone, 2004;34(3):547-556).

"Genetic factors substantially contribute to variation in bone mass. There is a controversy as to whether shared genetic factors exist for bone mass at different sites. We hypothesize that using a composite phenotypic...

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