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Reproductive Biology

Matrix metalloproteinase found essential for ovulation to occur

Published in Women's Health Weekly, May 27th, 2004

The matrix metalloproteinase Adamts-1 is necessary for normal ovulation in experimental mice, researchers have found, leading them to suggest that the Adamts-1 gene plays an important role in human female fertility.

The work was reported in the journal Biology of Reproduction by L. Mittaz, M.A. Pritchard, and colleagues at Monash University in Australia (Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod, 2004;70(4):1096-1105).

"Successful ovulation and implantation processes play a crucial role in female fertility. Adamts-1, a matrix metalloproteinase [MMP] with disintegrin and thrombospondin motifs,...

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