Ovarian Cancer

LOH at chromosome 9q22-31 is a frequent, early event in ovarian tumors

Published in Women's Health Weekly, June 17th, 2004

Loss of heterozygosity at chromosome 9q22-31 occurs frequently and early in development of ovarian tumors, researchers report.

Previous studies have pointed to chromosomal regions at 9q22-31 and 9q32-34 as possibly important in the development of ovarian cancer. J. Byrom and colleagues at Keele University, North Staffordshire, U.K., studied "LOH at 9q22-31 in 85 patients with epithelial ovarian cancer, 15 with non-epithelial tumors, and 16 with benign disease."

"Varying patterns of LOH were observed across the markers used between different tumors, the most common (71%) being interstitial discontinuous losses," the team reported. "LOH was frequent,...

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Source: Women's Health Weekly (2004-06-17)

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