Reproductive Biology

Protein expression studied in monkey endometrium

Published in Women's Health Weekly, June 17th, 2004

Expression patterns of the cyclooxygenase 1 and 2 (COX-1, COX-2) and microsomal prostaglandin synthases, mPGES, and cPGES, in the endometrium of monkeys during their menstrual cycle have been studied immunohistochemically by scientists in China.

"Cyclooxygenase (COX), a rate-limiting enzyme that produces prostaglandins (PGs) from arachidonic acid, exists in two isoforms, COX-1 and COX-2. PGE2 synthase (PGES) is a terminal prostanoid synthase and can enzymatically convert the cyclooxygenase product PGH(2) to PGE(2), including two isoforms: microsomal PGES (mPGES) and cytosolic PGES (cPGES). cPGES is predominantly linked with COX-1 to promote the immediate response. mPGES...

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Source: Women's Health Weekly (2004-06-17)

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