Gynecologic Cancers
Estradiol regulates enzyme in endocrine-regulated tissues via estrogen receptor
Published in Women's Health Weekly, June 17th, 2004
According to their study, published in the May 1, 2004, Cancer Research, CYP 1B1 "is a key enzyme in the metabolism of 17beta-estradiol (E2). CYP1B1 is mainly expressed in endocrine-regulated tissues, such as mammary, uterus, and ovary."
Yuki Tsuchiya and colleagues at Kanazawa University, hypothesizing that many CYP enzymes may be induces by substrates themselves, investigated if E2 regulates human CYP1B1 expression (Human CYP1B1 is regulated by estradiol via estrogen receptor. Cancer Res, 2004;64,3119-3125).
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