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Endocrinology

Neuropeptide Y gene expression increases in women as they age

Published in Women's Health Weekly, July 8th, 2004

Neuropeptide Y gene expression increases in women as they age, and it is not ovarian failure that triggers this increase, a study shows.

"Neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the infundibular (arcuate) nucleus of the hypothalamus are part of a reciprocal circuit regulating reproduction and energy balance. Based on studies showing an age-related decrease in POMC mRNA, we hypothesized that NPY gene expression would increase in older women," wrote C.M. Escobar and colleagues, University of Arizona.

They used in situ hybridization "to compare NPY mRNA levels between young (premenopausal) and older (postmenopausal) women. We also...

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