Gynecology
Infectivity-enhanced adenoviral vectors guide ovarian cancer gene therapy
Published in Women's Health Weekly, July 8th, 2004
"Ovarian carcinoma cells are often infected inefficiently by adenoviruses (Ad) due to low expression of coxsackie adenovirus receptors (CAR), hindering the application of adenovirus-mediated gene therapy in ovarian cancer. In this study, we explored a class of infectivity-enhanced Ad vectors, which contain CAR-independent targeting motifs RGD (Ad5.RGD), polylysine (Ad5. pK7), or both (Ad5.RGD.pK7), for their utility in ovarian cancer gene therapy using in vitro and in vivo model systems," researchers in the United States report.
"We found that these vectors infected...
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