Immunology
Invasive extravillous trophoblast appears to facilitate materno-fetal tolerance
Published in Women's Health Weekly, July 15th, 2004
"It is still not understood how the fetus escapes from being attacked by the maternal immune system. Recent reports based on mouse and in vitro models have suggested that the enzyme indoleamine 2,3-dioxygenase (IDO) is important for materno-fetal tolerance. IDO activity in the human placenta is known to be high and might lead to inhibition of T-cell proliferation, thus preventing fetal tissue from rejection by the maternal immune system," wrote A. Honig and colleagues, University of Wurzburg.
Using immunohistochemistry, this team...
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