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Ovarian Cancer

FHL2 is expressed in human ovarian cancer cells

Published in Women's Health Weekly, July 22nd, 2004

A study of the cytoplasmic tyrosine kinase pp125FAK and the Four and a Half LIM domain protein, FHL2, reveals both are expressed and form a protein complex in human epithelial ovarian cancer.

"Abnormal signal transduction arising from integrins and protein p-cosine kinases has been implicated in the initiation and progression of a variety of human cancers. Integrin-mediated signal transduction pathways require regulated cytoplasmic protein-protein interactions. However, little is known about integrin-associated proteins and ovarian cancer," said B. Gabriel and colleagues.

These scientists "investigated the association of pp125FAK, a cytoplasmic...

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