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Cervical Cancer

FRET inhibition effective for measuring AS-ODN activity in vivo

Published in Women's Health Weekly, July 22nd, 2004

The inhibition of fluorescence resonance energy transfer (FRET) can be used to effectively and directly to measure antisense oligodeoxynucleotides (AS-ODNs), which may be an effective approach to human papillomavirus type 16 (HPV-16)-related cervical cancer.

According to a recent study in the journal Luminescence, "Use of antisense nucleic acids to modulate expression of particular genes is a promising approach to the therapy of HPV-16-associated cervical cancer. Understandably, evaluation of the in vivo performance of synthetic AS-ODNs or ribozymes is of ultimate importance to development of effective antisense tools.

"Here we report the use...

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