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Herpesvirus

Theta defensins protect cells from HSV by inhibiting viral adhesion/entry

Published in Women's Health Weekly, July 22nd, 2004

Theta defensins protect cells from herpesvirus infection by inhibiting viral adhesion/entry.

According to a study from the United States, "We tested the ability of 20 synthetic theta defensins to protect cells from infection by type 1 and type 2 herpes simplex viruses (HSV-1 and -2, respectively).

"The peptides included rhesus theta defensins (RTDs) 1 to 3, originally isolated from rhesus macaque leukocytes, and three peptides (retrocyclins 1 to 3) whose sequences were inferred from human theta-defensin (DEFT) pseudogenes. We also tested 14 retrocyclin analogues, including the retro, enantio, and retroenantio forms of retrocyclin 1."

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