Breast Cancer

BRCA2 mutations more important in hereditary disease in Cyprus than BRCA1

Published in Women's Health Weekly, August 19th, 2004

BRCA2 gene mutations are more important in hereditary breast cancer in Cyprus than BRCA1 mutations, pathologists there have found.

"The entire coding regions of the two breast cancer susceptibility genes BRCA1 and BRCA2 from breast cancer patients from 40 Cypriot families with multiple cases of breast and ovarian cancer were sequenced," reported A. Hadjisavvas and colleagues, Cyprus Institute of Neurology and Genetics.

They found four protein-truncating mutations in six families.

"In BRCA1, a novel truncating mutation 5429delG was found in exon 21," the researchers said. "In BRCA2, three truncating mutations were detected: a...

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Source: Women's Health Weekly (2004-08-19)

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