Ovarian Cancer
Akt phosphorylation is key event in induction of telomerase activity by E-2
Published in Women's Health Weekly, August 19th, 2004
A. Kimura and colleagues "examined the mechanism by which estrogen regulates telomerase activity in Caov-3 human ovarian cancer cell lines, which express estrogen receptor (ER), to determine whether the regulation affects the expression and/or phosphorylation of the telomerase catalytic subunit (hTERT), 17beta-estradiol (E-2)-induced telomerase activity, and hTERT expression."
According to their paper in Oncogene, "Transient expression assays using luciferase reporter plasmids...
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