Preeclampsia
Hormonal control of leptin may be upregulated in preeclamptic placenta
Published in Women's Health Weekly, August 19th, 2004
"The placenta is a major source of leptin in the fetomaternal circulation, although its physiological role remains to be clarified. Leptin in the fetomaternal circulation is proposed to be a marker of acute stress in the fetus, and the fetus suffering from pre-eclampsia would be under chronic stress," wrote S. Iwagaki and colleagues, Gifu University, Japan.
"In 16 preeclamptic placentas, the expressions of leptin, hypoxia-inducible factor 1a (HIF1alpha), and leptin receptor mRNAs were analyzed by semi-quantitative...
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