Endocrinology
Compound in contraceptives, HRT antagonizes behavioral effects of estrogen
Published in Women's Health Weekly, August 19th, 2004
"Medroxyprogesterone acetate (MPA) commonly is used in contraception and hormone replacement therapy. However, little is known about its effects within the central nervous system. Using ovariectomized pigtail macaques ( Macaca nemestrina), we evaluated the potential for MPA to antagonize estradiol (E2) effects on female sociosexual behavior," said K. Pazol and colleagues, Emory University.
They sequentially administered placebo, then E2 along, then E2 plus...
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