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Cervical Cancer

Mechanism described by which POU transcription factor represses growth in vitro

Published in Women's Health Weekly, September 2nd, 2004

Results of a study from Japan suggest the POU transcription factor human Skn-1a "represses growth of the cervical cancer cells through the partial resumption of the differentiation pathway followed by slow suppression of cell replication and apoptosis."

"The POU transcription factor human Skn-1a (hSkn-1a) specifically promotes the proliferation of keratinocytes and enhances their differentiation," said Y. Enomoto and colleagues at Japan's National Institute of Infectious Diseases.

The research team "examined the effects of hSkn-1a on cervical cancer cell lines of epithelial origin, in which the differentiation program is interrupted."

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