Amyotrophic Lateral Sclerosis

Spermidine and spermine levels higher in female ALS patients than males

Published in Women's Health Weekly, October 7th, 2004

Study data suggest that regulation of polyamine levels is maintained in end-stage amyotrophic lateral sclerosis, and, interestingly, show that in female patients, spermidine and spermine levels in the ventral horn region are higher than those of males.

T. Ekegren and colleagues, University of Uppsala Hospital, Sweden, measured postmortem putrescine, spermidine, and spermine (all polyamines) levels from the spinal cords of seven amyotrophic lateral sclerosis (ALS) patients and seven controls.

According to the researchers, their "method consisted of precolumn derivatization of the polyamines, followed by high-performance liquid chromatography analysis...

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Source: Women's Health Weekly (2004-10-07)

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